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COMMUNICATIONS
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3201-3204
Neurosteroid Analogues. 8. Structure-Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3 ,5)- and (3,5 )-3-Hydroxypregnan-20-one
Douglas F. Covey,
Mingcheng Han,
A. Sampath Kumar,
Maria Antonette M. de la Cruz,
Eric S. Meadows,
Yuefei Hu,
Alicia Tonnies,
Devi Nathan,
Melissa Coleman,
Ann Benz,
Alex S. Evers,
Charles F. Zorumski, and
Steven Mennerick
[Full Article -
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3205-3208
Discovery of Potent Antagonists of the Interaction between Human Double Minute 2 and Tumor Suppressor p53
Carlos García-Echeverría,
Patrick Chène,
Marcel J. J. Blommers, and
Pascal Furet
[Full Article -
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ARTICLES
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3210-3217
Conformationally Constrained Analogues of Diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG Lactones in Binding to Protein Kinase C
Hirokazu Tamamura,
Bruno Bienfait,
Kassoum Nacro,
Nancy E. Lewin,
Peter M. Blumberg, and
Victor E. Marquez[Full Article -
PDF]
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3218-3225
Benzothiadiazine Dioxide Dibenzyl Derivatives as Potent Human Cytomegalovirus Inhibitors: Synthesis and Comparative Molecular Field Analysis
Ana Martinez,
Carmen Gil,
Maria I. Abasolo,
Ana Castro,
Ana M. Bruno,
Concepción Perez,
Columbiana Prieto, and
Joaquín Otero[Full Article -
PDF]
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3226-3232
Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors
Sébastien Maignan,
Jean-Pierre Guilloteau,
Stéphanie Pouzieux,
Yong Mi Choi-Sledeski,
Michael R. Becker,
Scott I. Klein,
William R. Ewing,
Henry W. Pauls,
Alfred P. Spada, and
Vincent Mikol[Full Article -
PDF]
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3233-3243
GRid-INdependent Descriptors (GRIND): A Novel Class of Alignment-Independent Three-Dimensional Molecular Descriptors
Manuel Pastor,
Gabriele Cruciani,
Iain McLay,
Stephen Pickett, and
Sergio Clementi[Full Article -
PDF]
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3244-3256
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors
Allan Wissner,
Dan M. Berger,
Diane H. Boschelli,
M. Brawner Floyd, Jr.,
Lee M. Greenberger,
Brian C. Gruber,
Bernard D. Johnson,
Nellie Mamuya,
Ramaswamy Nilakantan,
Marvin F. Reich,
Ru Shen,
Hwei-Ru Tsou,
Erik Upeslacis,
Yu Fen Wang,
Biqi Wu,
Fei Ye, and
Nan Zhang[Full Article -
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3257-3266
DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins
Robert V. Fishleigh,
Keith R. Fox,
Abedawn I. Khalaf,
Andrew R. Pitt,
Martin Scobie,
Colin J. Suckling,
John Urwin,
Roger D. Waigh, and
Stephen C. Young[Full Article -
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3267-3273
Nonnucleoside Human Cytomegalovirus Inhibitors: Synthesis and Antiviral Evaluation of (Chlorophenylmethyl)benzothiadiazine Dioxide Derivatives
Ana Martinez,
Carmen Gil,
Concepción Perez,
Ana Castro,
Columbiana Prieto,
Joaquín Otero,
Graciela Andrei,
Robert Snoeck,
Jan Balzarini, and
Erik De Clercq[Full Article -
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3274-3282
Cholic Acid Derivatives as 1,2,4,5-Tetraoxane Carriers: Structure and Antimalarial and Antiproliferative Activity
Dejan Opsenica,
Gabriela Pocsfalvi,
Zorica Jurani ,
Bernard Tinant,
Jean-Paul Declercq,
Dennis E. Kyle,
Wilbur K. Milhous, and
Bogdan A.  olaja[Full Article -
PDF]
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3283-3294
Chemical Synthesis and Pharmacology of 6- and 7-Hydroxylated 2-Carbomethoxy-3-(p-tolyl)tropanes: Antagonism of Cocaine's Locomotor Stimulant Effects
Lianyun Zhao,
Kenneth M. Johnson,
Mei Zhang,
Judith Flippen-Anderson, and
Alan P. Kozikowski[Full Article -
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3295-3303
Synthesis of Potent Agonists of the D-myo-Inositol 1,4,5-Trisphosphate Receptor Based on Clustered Disaccharide Polyphosphate Analogues of Adenophostin A
Martin de Kort,
Vanessa Correa,
A. Rob P. M. Valentijn,
Gijs A. van der Marel,
Barry V. L. Potter,
Colin W. Taylor, and
Jacques H. van Boom[Full Article -
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3304-3314
A New Class of Antituberculosis Agents
Paul B. Jones,
Nikki M. Parrish,
Todd A. Houston,
Anthony Stapon,
Niharika P. Bansal,
James D. Dick, and
Craig A. Townsend[Full Article -
PDF]
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3315-3321
Anti-Helicobacter pylori Agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives
Yousuke Katsura,
Tetsuo Tomishi,
Yoshikazu Inoue,
Kazuo Sakane,
Yoshimi Matsumoto,
Chizu Morinaga,
Hirohumi Ishikawa, and
Hisashi Takasugi[Full Article -
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3322-3334
Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis
Teodozyj Kolasa,
David E. Gunn,
Pramila Bhatia,
Anwer Basha,
Richard A. Craig,
Andrew O. Stewart,
Jennifer B. Bouska,
Richard R. Harris,
Keren I. Hulkower,
Peter E. Malo,
Randy L. Bell,
George W. Carter, and
Clint D. W. Brooks[Full Article -
PDF]
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3335-3343
New Histamine H3-Receptor Ligands of the Proxifan Series: Imoproxifan and Other Selective Antagonists with High Oral in Vivo Potency
Astrid Sasse,
Bassem Sadek,
Xavier Ligneau,
Sigurd Elz,
Heinz H. Pertz,
Peter Luger,
C. Robin Ganellin,
Jean-Michel Arrang,
Jean-Charles Schwartz,
Walter Schunack, and
Holger Stark[Full Article -
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BRIEF ARTICLES
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3344-3347
Design, Synthesis, and Pharmacological Characterization of 4-[4,4-Dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a High-Affinity Nonsteroidal Androgen Receptor Ligand
Marcian E. Van Dort,
Diane M. Robins, and
Bess Wayburn[Full Article -
PDF]
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3348-3350
3-Deoxyclocinnamox: The First High-Affinity, Nonpeptide  -Opioid Antagonist Lacking a Phenolic Hydroxyl Group
Ian Derrick,
Claire L. Neilan,
Jennifer Andes,
Stephen M. Husbands,
James H. Woods,
John R. Traynor, and
John W. Lewis[Full Article -
PDF]
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